Actor Christopher Reeve, star of the Superman films in the 1970s and 80s, has died.
The 52-year-old had been suffering from an infection as a result of a pressure wound and died on Sunday, his publicist Wesley Combs said.
He had suffered a cardiac arrest at his New York home and slipped into a coma, Mr Combs added.
Reeve was paralysed nine years ago when he broke his neck after being thrown from a horse.
Millions of fans
He had become an advocate for spinal cord injury research.
In recent years, he had regained sensation in some parts of his body.
He had also returned to acting, appearing in a 1998 production of Rear Window, a modern version of the Alfred Hitchcock thriller about a man in a wheelchair who becomes convinced that a neighbour has been murdered.
The role won him a Screen Actors Guild award.
Reeve's wife Dana said in a statement: "On behalf of my entire family, I want to thank Northern Westchester Hospital for the excellent care they provided to my husband.
"I also want to thank his personal staff of nurses and aides, as well as the millions of fans from around the world who have supported and loved my husband over the years."
Reeve was a virtual unknown before he shot to superstardom in the 1978 blockbuster Superman.
Thanks to meticulous preparation and close physical resemblance to the comic-strip hero, producers gave him the part.
The film and its three sequels turned Reeve into a worldwide star and grossed $300m.
Reeve broke his neck in May 1995 when he was thrown from his horse during an equestrian competition in Culpeper, Virginia.