At the 2010 Brisbane International, Ivanovic reached her first semifinal since Indian Wells, defeating Jelena Dokic, Timea Bacsinszky and Anastasia Pavlyuchenkova. However, Ivanovic lost to wild card Justine Henin, 6–3, 6–2. This was Henin's first return to tennis since her retirement.
At the 2010 Australian Open, Ivanovic lost lost in the second round to Gisela Dulko 6–7(6), 7–5, 6–4. Ana Ivanovic withdrew from Dubai with shoulder tendenitis. Her next event will be the 2010 BNP Paribas Open.