Several huge explosions have rocked Pakistan's northwest tribal region near the the Afghan border.
Six missiles from a suspected US drone were dropped in a cross border attack near Miranshah, capital of North Waziristan, Pakistani security sources told Al Jazeera.
Witnesses on Monday reported at least three people killed and another 20 wounded.
The attack targeted a religious school founded by Jalaluddin Haqqani, a Taliban leader, as well as nearby houses.
Al Jazeera's Kamal Hyder said: "It is not the first time that the madrassa [school] was targeted. In the past, special forces have gone into the madrassa looking for Haqqani."
Reuters news agency quoted one of Haqqani's sons as saying the commander was unharmed and in Afghanistan with his older son.
"Haqqani and Sirajuddin were in Afghanistan at the time of the attack. They are alive," Badruddin, Haqqani's third son, said.
Badruddin also said one of his aunts was killed in the attack, and women and children were among the wounded.
Monday's attack is the fourth suspected US cross-border strike in the rugged tribal region in almost a week.