What's the main thing that holds YOU back in life?
We all hear the term 'depression' bandied about. Oh of course debilitating mental illness exists, but as we're all individuals, it's quite often not helpful to use such an umbrella term in my opinion. It's also sometimes even more destructive to the self-esteem to believe that you have a disease of the mind: it becomes self-perpetuating.
So, let's break it down. What is the main sentiment, if you can sum it up in one word, which holds you back. Choose one, even if the others seem applicable as well, that, if tackled, would emancipate you enough to work on the rest.