Spybot when you have it search for all problems, then click "fix problems" or whatever and it shoud delete them for you.
In C: drive delete only things like say "One time search assistant" or "IE Hotbar"..things that sound tacky, cheap and aint microsoftish. Usualy it wont let you delete any really important things and if you do you can always system restore it..its like time travel.
System restore...right, Start=Control Panel=Performance and Maintenence=System Restore (Top left corner) then follow its instructions, choose a date maybe a week ago if all was well then and you havnt installed any new programes. (I find after system restoremI have to re-install some non standard programes like Mesenger version 6 and Kazaa but most seem fine).
Blast it means delete, kill what ever just get rid of.
Trt to avoid System restore unless spybot and c drive dont work just to avoid needing to reinstall a few programes. (Real player also is one you need to reinstall, the files are still on your comp u just need to re instal them / set up them)